Hair of the Dog
1212 washington - downtown. wahington's only dive bar; great atmosphere and cheap drink prices. cheers-type environment, where everybody knows each other's name, and strangers are warmly welcomed. service is a strong point, and this place is perhaps st. louis' best watering hole.
Pinup Bowl
Pinup Bowl, 6191 Delmar, (http://www.pinupbowl.com/). Bowling alley and martini lounge open till 3AM.
Sub Zero Vodka Bar
Sub Zero Vodka Bar, 308 N. Euclid Av. in the Central West End, +1 314 367-1200, (http://www.subzerovodkaba...).
Venice Cafe
1903 pestalozzi st south city area, +1 314 772-5994, (http://www.thevenicecafe.com/). a mosaic-covered bar with outside sitting features nightly music.
Most tourists will be familiar with St. Louis' world famous Anheuser-Busch brewery, especially its signature variety Budweiser, or their best-seller Bud Light. However, unless you are accustomed to American style pilsners, it is unlikely you will find these and other Anheuser-Busch brands suit your palate. For those more familiar with European brews or who have been caught up in the domestic microbrewery explosion interested in sampling a local brewery's product, the Saint Louis Brewery's Schlafly microbrews are more likely to satisfy. Schlfaly is the largest microbrewery in St. Louis but not the only one. 4Hands, Civil Life, Urban Chestnut, Square One, Perennial Artisan Ales, are just a few of the other breweries in town. They are definitely worth a look.
If you are would rather explore rather than choose one specific establishment, two areas in St. Louis are great for wandering from location to location: The Central West End featuring Sub-Zero Vodka Bar, the Drunken Fish, Tom's Bar, the Loading Zone, Mandarin Lounge, and Bissinger's Chocolate Lounge all off Euclid Ave, and Downtown centered around Washington Ave featuring Kyo, Home, Pepper Lounge, Lucas Park Grille, Plush, Nectar, and rue13. St. Louis's MetroLink system is great if you prefer not to drive, but much of the line will stop running by 1:00AM.
St. Louis is also home to a number of gay and lesbian friendly nightlife options. From busy bars to energetic dance clubs, make sure to stop by rBar, Atomic Cowboy, Novak's, and the Complex. Much of these are on Manchester Rd in Forest Park Southeast.
The Big Bang
The Big Bang, 807 N. Second St. Laclede's Landing, +1 314 241-BANG (http://www.thebigbangbar.com/). Two dueling piano players lead the crowd in a rock 'n' roll sing-along show.
Blueberry Hill
Blueberry Hill, 6504 Delmar Blvd, +1 314 727-4444, (http://www.blueberryhill.com/). Restaurant, darts, bar open till 3AM. Located on the Delmar loop.
Cicero's
Cicero's, 6691 Delmar in University City, +1 314 862-0009, (http://www.ciceros-stl.co...). Cicero's probably derives the bulk of its income from the pizza joint upstairs, which is fair, because the pizza is good. That said the main interest for the traveler is the well equipped bar and the venue downstairs, which hosts touring indie and rock bands.